تقنية “لتهدئة” الأورام

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الأساسي

  • يوجد بروتين NR2F1 في نواة الخلايا ، ويعمل على التعبير عن الجينات.
  • سوف يمنع العلاج الانتكاس في مرضى السرطان.
  • لتأكيد هذه النتائج ، ستكون هناك حاجة لدراسات بشرية.

الخلايا السرطانية هي سبب تكون الورم. أحيانًا يهرب البعض وينتقل إلى أعضاء أخرى. سيشكلون بعد ذلك ما يسمى بالسرطانات الثانوية ، والتي تسمى أيضًا النقائل. أولئك “الجديد“غالبًا ما يكون علاج الأورام أكثر صعوبة. في بعض الأحيان تتحرك الخلايا السرطانية ولكنها تبقى”نائما“لعدة سنوات ، قبل إعادة التنشيط والتكاثر. دراسة نشرت في تيمجلة الطب التجريبي، يشهد على فعالية طريقة للحفاظ عليها خلايا سرطاننائم “.

دور بروتين NR2F1

لقد وجد مؤلفو هذا البحث بالفعل أن قدرة خلايا سرطان للبقاء خاملًا يتم التحكم فيه بواسطة بروتين يسمى NR2F1. إنه قادر على دخول نواة الخلية ، للعمل على الجينات لتفعيل برنامج يمنع الخلايا السرطانية من التكاثر. مستويات البروتين NR2F1 منخفضة في الأورام الأولية ولكنها مرتفعة في الخلايا السرطانية النائمة. عندما تبدأ الخلايا السرطانية في التكاثر مرة أخرى وتتشكل ورم خبيث، تنخفض مستوياته مرة أخرى. “لذلك اعتقدنا أن تنشيط NR2F1 باستخدام جزيء صغير يمكن أن يكون استراتيجية سريرية مثيرة للاهتمام للحث على نعاس الخلايا السرطانية ومنع تكرار حدوث ورم خبيث.“، يوضح Julio A. Aguirre-Ghiso ، المؤلف المشارك للدراسة.

اختبار على الفئران

مع هذا الجزيء ، طوروا عقارًا يسمى C26 ، قادرًا على تنشيط بروتين NR2F1. قاموا بحقن الخلايا من سرطان الرأس والعنق البشري في الفئران. ثم قاموا بفحص ما إذا كان C26 قادرًا على منع تكاثر الخلايا. عادة ، عندما يتم حقن هذه الخلايا في الفئران ، فإنها تشكل أورامًا أولية كبيرة ، وبعد ذلك ، عند إزالتها عن طريق الجراحة ، تظهر النقائل الرئوية. “أدى العلاج بـ C26 إلى تقليل حجم الأورام الأولية ، وبعد الجراحة ، أدت الجرعات الإضافية من C26 إلى منع نمو الأورام النقيلية تمامًا “، لاحظ المؤلفين. ال رئتين تحتوي القوارض فقط على عدد قليل من الخلايا السرطانية النائمة غير القادرة على التكاثر حتى بعد التوقف عن العلاج.

دواء محتمل لسرطان الثدي

قد تكون الأدوية التي تنشط NR2F1 مفيدة بشكل خاص في سرطان الثدي“، حسب تقدير ماريا سوليداد سوسا أورام الثدي نوع ER + ، لمستقبلات هرمون الاستروجين إيجابية ، غني ببروتين NR2F1 ، لذا فهي أكثر تقبلاً لهذا الدواء. نظرًا لأن العلاج يزيد من مستويات هذا البروتين ، فقد يكون مفيدًا في إدارة أنواع أخرى من سرطان.



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